TABLE 3.

Enzyme kinetics

Enzyme classSourceKm (μM)Reference(s)
BenzylpenicillinAmpicillinCefazolinCephaloridineCefoxitinCefotaximeAztreonamImipenemb
C E. cloacae 0.60.41,500700.0240.010.00120.04 99, 100
C. freundii 0.40.2600350.2500.0050.00140.085 99, 100
E. coli K-124.43.54001700.6501.70.00120.8 99, 100
S. marcescens 1.70.015402750.3120.0580.06 99, 100, 148
P. aeruginosa 1.70.5a200.050.20.0500.026 99, 100
ACT-12.11.7430>2000.50.070.0120.37 25
MIR-10.40.16a930.7540.0040.15 25
CMY-112.2541100.0550.0150.010.05 25
CMY-20.40.16a930.070.0012<0.003ND 25
ATEM-215-20226802,1003,000 204
B. licheniformis 7614312135205 204
DOXA-29101630128210NH 96
  • a Biphasic kinetics.

  • b ND, not determined; NH, no hydrolysis detected.