TABLE 7.

Studies that primarily assessed the efficacy and/or toxicity of intrathecal/ventricular polymyxins for CNS infection with Acinetobacter baumanniia

ReferencebStudy designNo. of patients treated with colistinNeurotoxicity
Paramythiotou et al. (416)Retrospective case series2 (all infected with A. baumannii)Nil
Ng et al. (398)Retrospective case series5 (all infected with A. baumannii)Chemical meningitis (60%)
Kasiakou et al. (286)Case report1 (five episodes [two A. baumannii episodes, two P. aeruginosa episodes, and one Enterobacter cloacae episode])Nil
Al Shirawi et al. (7)Case report1 (infected with A. baumannii)Nil
Bukhary et al. (67)Case report1 (infected with A. baumannii)Nil
Fernandez-Viladrich et al. (166)Retrospective case series2 (all infected with A. baumannii)Nil
Vasen et al. (576)Case report1 (infected with A. baumannii)Nil
Benifla et al. (25)Case report1 (infected with A. baumannii)Nil
  • a The outcome in all studies was 100% cure. None of the studies reported any nephrotoxicity.

  • b All studies were noncomparative, and only select case reports were included.