TABLE 7.

Antifungal susceptibility data for 403 clinical isolates in the United States (January 2000 to May 2007)a

SpeciesAntifungal agentNo. of isolatesMIC, μg/mlb
Range50%90%
S. prolificans Amphotericin B240.5->16>16>16
5-Flucytosine2>64>64>64
Fluconazole138->6432>64
Itraconazole200.125->81>8
Ketoconazole41-2NDcND
Voriconazole300.25->80.5>8
Posaconazole110.5->84>8
Caspofungin180.25->168>16
Micafungin10.5NDND
Anidulafungin0NDNDND
S. apiospermum Amphotericin B1330.5->16>16>16
5-Flucytosine13>64>64>64
Fluconazole614->6432>64
Itraconazole1310.125->814
Ketoconazole281-222
Voriconazole1780.25->80.51
Posaconazole550.25-412
Caspofungin1050.25->16>16>16
Micafungin60.125-0.250.25ND
Anidulafungin20.25-0.5NDND
Scedosporium sp.Amphotericin B31>16>16>16
5-Flucytosine3>64>64>64
Fluconazole5>64>64>64
Itraconazole20>8>8>8
Ketoconazole3>16>16>16
Voriconazole49>8>8>8
Posaconazole32>8>8>8
Caspofungin364->168>16
Micafungin2>16>16>16
Anidulafungin1>16>16>16
  • a Testing was performed by the Fungus Testing Laboratory of the University of Texas Health Science Center at San Antonio.

  • b MICs were determined as described in CLSI document M38-A for filamentous fungi (307). MICs were read at 48 h. Amphotericin B, caspofungin, micafungin, and anidulafungin were tested in antibiotic medium 3, whereas all azoles and flucytosine were tested in RPMI 1640.

  • c ND, not determined.