TABLE 5.

In vitro studies of drug combinations against Scedosporium spp.

SpeciesNo. of strainsDrug combination (drug A + drug B)Median MIC (range), μg/mlInteractionb (% of strains)Reference
Drugs aloneDrugs in combination
Drug ADrug BDrug ADrug B
S. prolificans 20Terbinafine + itraconazole32 (4->64)>32 (>32)1 (0.5-4)1 (0.5-16)SYN (85), ADD (15) 288
5Terbinafine + voriconazole>64 (>64)8 (4-16)9.51 (2-32)0.71 (0.03-2)SYN (100) 287
5Terbinafine + miconazole>64 (>64)64 (8->64)2 (1-4)2 (0.13-8)SYN (100) 287
30Amphotericin B + pentamidine32 (4-32)64 (8-128)2 (1-4)8 (2-32)SYN (93), ADD (7) 4
4Voriconazole + micafungin4 (2-4)256 (256)1 (1-2)0.5 (13-64)SYN (75), ADD (15) 188
17Amphotericin B + micafungin>8 (1->8)>32 (>32)4 (0.5-8)16 (0.06-16)SYN (84), ADD (16) 489
S. apiospermum 3Voriconazole + micafungin0.13 (0.13-0.25)32 (0.25-128)0.06 (0.06)0.25 (0.13-0.5)SYN (66), ADD (33) 188
19Amphotericin B + micafungin8 (0.5->8)2 (1->32)1 (0.12-8)1 (0.12-8)SYN (31), ADD (69) 489
8Amphotericin B + miconazole1 (0.25-2)0.25 (0.13-0.5)NAaNASYN (13), ADD (63) 458
8Amphotericin B + itraconazole1 (0.25-2)0.25 (0.03-0.5)NANASYN (25), ADD (13) 458
8Amphotericin B + fluconazole1 (0.25-2)16 (4-32)NANASYN (38), ADD (50) 458
  • a NA, not available.

  • b Synergy (SYN) was defined as being when fractional inhibitory indices were ≤0.5. Additivity (ADD) was defined as being when fractional inhibitory indices were >0.5 and ≤1. The remaining isolates showed indifferent interactions (fractional inhibitory indices of >1 and <4). No antagonism was observed (fractional inhibitory index, >4).