TABLE 18.

Activities of three echinocandin antifungal agents against 315 isolates of fluconazole-resistant Candida speciesa

Species (no. of isolates tested)Antifungal agentCumulative % susceptible at MIC (μg/ml)
0.0070.0150.030.060.120.250.512
C. albicans (41)Anidulafungin15426695959598100
Caspofungin210619595989898100
Micafungin1076959898100
C. glabrata (110)Anidulafungin13368198100
Caspofungin01599196100
Micafungin199397100
C. krusei (146)Anidulafungin1340829799100
Caspofungin011428297100
Micafungin12269399100
All Candida spp. (315)Anidulafungin39428194969899100
Caspofungin12316687979999100
Micafungin9446093969899100
  • a MICs were determined in RPMI broth, with a 24-h incubation and a prominent inhibition endpoint. Data are compiled from references 157 and 220.