TABLE 16.

Clinical and in vitro resistance to echinocandins in patients with candidiasisa

StudySpeciesInfection typeNo. of isolatesEchinocandin MIC range (μg/ml)bCoresistance
Moudgal et al. (167)C. parapsilosisEndocarditis62->16*Caspofungin, micafungin, azoles
Dodgson et al. (63)C. glabrataCandidemia150.12->8*Caspofungin, azoles
Krogh-Madsen et al. (120)C. glabrataCandidemia40.5->8*Caspofungin, amphotericin B, azoles
Hernandez et al. (102)C. albicansEsophagitis30.25->64*Caspofungin, azoles
Laverdiere et al. (126)C. albicansEsophagitis40.03-2†Micafungin, caspofungin, azoles
  • a All patients were treated with caspofungin, with the exception of those in the study of Laverdiere et al. (126) (micafungin).

  • b Symbols: *, caspofungin MICs; †, micafungin MICs.