Clinical and in vitro resistance to echinocandins in patients with candidiasisa

StudySpeciesInfection typeNo. of isolatesEchinocandin MIC range (μg/ml)bCoresistance
Moudgal et al. (167) C. parapsilosis Endocarditis62->16*Caspofungin, micafungin, azoles
Dodgson et al. (63) C. glabrata Candidemia150.12->8*Caspofungin, azoles
Krogh-Madsen et al. (120) C. glabrata Candidemia40.5->8*Caspofungin, amphotericin B, azoles
Hernandez et al. (102) C. albicans Esophagitis30.25->64*Caspofungin, azoles
Laverdiere et al. (126) C. albicans Esophagitis40.03-2†Micafungin, caspofungin, azoles
  • a All patients were treated with caspofungin, with the exception of those in the study of Laverdiere et al. (126) (micafungin).

  • b Symbols: *, caspofungin MICs; †, micafungin MICs.