TABLE 25.

Consideration of risk of invasive fungal infections (IFI) in assessing the impact of fluconazole prophylaxis among critically ill and surgical patients: applicability of meta-analysis resultsa

Estimated riskExample(s)bIncidence (no. of IFI/100 patients)No. of IFI avoided/100 patientsNo. of patients needed to treat to prevent one episode of IFI
Without prophylaxisWith prophylaxis
Low (<1%)Absence of risk factors*10.470.53188
Average (2%)Unselected intensive care unit population*20.941.0694
High (11%)One of the following risk factors: diabetes, new-onset hemodialysis, or TPN prior to intensive care unit entry or broad-spectrum antibiotics†115.25.817
Highest (20%)One of the following risk factors: diabetes, new-onset hemodialysis, or TPN prior to intensive care unit entry and broad-spectrum antibiotics*209.410.69
  • a Data compiled from the study of Playford et al. (233).

  • b Symbols: *, based on reference 252; †, based on reference 187.