TABLE 17.

Comparison of the in vitro susceptibilities of Candida isolates collected before (1992 to 2000) and after (2001 to 2004) the clinical introduction of caspofungina

YrNo. of isolates testedCumulative % susceptible at indicated MIC (μg/ml)
0.0070.0150.030.060.120.250.51248>8
1992-20003,322b2338688488939899999999100
20011,783163568838895999999100
20022,2392842688185919899999999100
20032,287728607881899899999999100
20041,888114547882899899999999100
2001-20048,1971330628084919899999999100
  • a All isolates were from blood or normally sterile-site infections. All isolates were tested in RPMI 1640 broth with a 24-h incubation period and a prominent reduction endpoint criterion (MIC-2). Data are compiled from reference 224.

  • b Eight of the 11 isolates for which the MICs were ≥2 μg/ml are glucan synthesis mutants.