TABLE 4.

Susceptibility to antimicrobial agents of C. jejuni 11168 lacking or overexpressing an efflux pump

C. jejuni strain or characteristicaMIC (μg/ml)b
CIPERYAMPTETCHLTRIC
CLSI suggested breakpoint concn48*32*16*32*
BSAC suggested breakpoint concn116*2*8*
Wild type0.250.540.514
cmeB::aph0.120.2520.250.51
cmeB+++8432161632
cmeF::aph0.250.50.50.2511
  • a +++, overexpressing mutant.

  • b *, recommended breakpoint concentration for Enterobacteriaceae (no recommended breakpoint concentrations for C. jejuni exist); CIP, ciprofloxacin; ERY, erythromycin; AMP, ampicillin; TET, tetracycline; CHL, chloramphenicol; TRIC, triclosan. Data are taken from Pumbwe and Piddock (175) and Pumbwe et al. (176).