TABLE 3.

Recommended treatment for infections with ESBL-producing organisms

Infection typeTherapy of choiceSecond-line therapy
Urinary tract infectionQuinoloneaAmoxicillin/clavualante
BacteremiaCarbapenemQuinolonea
Hospital-acquired pneumoniaCarbapenemQuinolonea
Intra-abdominal infectionCarbapenemQuinolonea (plus metronidazole)
MeningitisMeropenemIntrathecal polymyxin B
  • a If the organism is quinolone susceptible.