TABLE 6.

In vitro activities of selected antibiotics against B. pseudomallei

AgentSource (no. of isolates)MIC (mg/liter)aReference(s)
50%90%Range
AmikacinUnited Kingdom (12)NRb6432-64 297
AmoxicillinVarious (127)>64>6432-256 18, 76
Amoxicillin-clavulanateVarious (406)2-84-82/0.5->512 18, 76, 222, 232, 297, 392
AmpicillinVarious (199)32-6432->640.25->256 232, 402
Ampicillin-sulbactamThailand (199)480.25-128 402
AzithromycinUnited Kingdom collection (unknown)64>641->64 232
AzlocillinAustralia (100)242-16 18
AztreonamVarious (423)4-168-322->256 18, 76, 402, 497
BiapenemThailand (124)0.25-0.50.25-20.06-2 392
CarbenicillinCanadian collection (20)NR10050-200 158
CarumonamThailand, United Kingdom collection (211)24-80.5-256 297, 402
CefamandoleAustralia (100)>64>64>64 23
CefazolinAustralia (100)>64>64>64 23
CefepimeThailand (97)12.512.53.13-50 497
CefiximeThailand (199)241-16 402
CefoperazoneThailand, Hong Kong (27)8168-16 76
Cefoperazone-sulbactamMalaysia (50)NR4NR 244
CefotaximeVarious (324)2-43.13-80.78-12.5 18, 23, 76, 497
CefoxitinAustralia (100)>64>64>64 23
CeftazidimeAustralian clinical (170)1-3 222
CeftazidimeVarious (887)0.78-21-40.25-256 18, 76, 222, 232, 346, 392, 402, 497
CeftriaxoneVarious (127)2-44-82-8 18, 76
CefuroximeVarious (127)16-6432->6416->64 23, 76, 232
CefuzonamThailand (97)3.136.251.56-25 497
CephalexinAustralia (100)>64>64>64 23
CephalothinAustralian clinical isolates (100)>64>64>64 23
ChloramphenicolVarious (409)6.3-166.3-321.6->200 76, 155, 182, 222, 232, 346, 497
CiprofloxacinVarious (423)2-43.13-81-16 18, 76, 232, 402, 497
CycloserineU.S. NIHc collection (51)32428-64 182
DoxycyclineVarious (277)0.5-41-80.5-16 155, 182, 222, 232
EnoxacinThailand (97)6.256.253.13-25 497
ErythromycinU.S. NIH collection (51)12812816-128 182
FosfomycinThailand (97)>200>200>200 497
GentamicinVarious (63)32640.125-128 182, 232, 297
ImipenemVarious (590)0.39-0.50.78-10.12-8 222, 232, 392, 402, 497
KanamycinU.S. NIH collection (51)8321-32 182
LomefloxacinThailand (97)6.256.253.13-25 497
MeropenemAustralia, Thailand (391)0.78-10.78-10.25-4 222, 392, 497
MinocyclineThailand (97)1.563.130.78-3.13 497
MoxalactamAustralia (100)8164-16 23
Nalidixic acidThailand (97)25503.13->200 497
NeomycinU.S. NIH collection (51)641288->128 182
NetilmicinUnited Kingdom collection (12)NR12816-128 297
NorfloxacinThailand, Australia (197)4-12.58-12.51-50 18, 497
NovobiocinU.S. NIH collection (51)8164-32 182
OfloxacinVarious (124)2-6.256.25-80.78-12.5 76, 232, 497
PanipenemThailand (124)0.510.06-16 392
PiperacillinVarious (605)1-42-80.25-16 18, 76, 222, 232, 297, 402, 497
Piperacillin-tazobactamThailand (199)110.25-8 402
RifampinVarious (175)8-2516-643.13-128 76, 182, 232, 497
SulfamethoxazoleVarious (97)16-5050->6412.5->64 232, 497
TemafloxacinThailand (296)3.13-86.25-160.25-32 402, 497
TetracyclineVarious (175)4-6.258-160.78-16 76, 182, 346, 497
TicarcillinVarious (326)128->256256->25664->256 18, 76, 402
Ticarcillin-clavulanateThailand (199)4-164-161->256 18, 76, 402
TrimethoprimThailand, United Kingdom collection (97)16-2525->641.56->64 232, 497
TMP-SMXdThailand (97)1/19-5/252/28->640.625/3.125-20/100 76, 222, 232, 331, 346, 497
TosufloxacinThailand (97)1.563.130.39-6.25 497
  • a 50% and 90%, MICs at which 50 and 90% of isolates are inhibited, respectively.

  • b NR, not recorded.

  • c NIH, National Institutes of Health.

  • d MICs vary with testing method.