TABLE 9.

Intensive-phase antibiotic regimens used for patients with normal renal function

Regimen
Royal Darwin Hospital (111)Other recommended (472)
(i) TMP-SMX at 8/40 mg/kg (up to 320/1,600 mg) every 12 h and ceftazidime at 50 mg/kg (up to 2 g) intravenously every 6 h or (ii) meropenem at 25 mg/kg (up to 1 g) intravenously every 8 h and G-CSF (filgrastim) 300 μg intravenously for 10 days if patient has septic shock (duration of therapy at least 14 days, and longer (4 to 8 weeks) for deep-seated infection, osteomyelitis, or septic arthritis; patients may be discharged for outpatient administration of ceftazidime if clinically stable)(i) Ceftazidime at 40 mg/kg intravenously every 8 ha, (ii) ceftazidime at 19 mg/kg intravenously (bolus) followed by 3.5 mg/kg per h as a continuous infusion, (iii) imipenem at 20 mg/kg intravenously every 8 hb, or (iv) ampicillin-clavulanate at 20/4 mg/kg intravenously every 4 hc (duration of therapy at least 10 days or until clear clinical improvement)
  • a Without TMP-SMX; first-line regimen at Sapprasithiprasong Hospital, Ubon Ratchathani.

  • b Second-line regimen for treatment failure with ceftazidime at Sapprasithiprasong Hospital.

  • c Second-line regimen for empiric treatment of melioidosis at Sapprasithiprasong Hospital.