TABLE 2.

Genes associated with survival and virulence identified in the B. pseudomallei genomea

SurvivalVirulence
Secondary metabolism: possible antibiotic, surfactant, siderophore biosynthetic pathways (including fur)Secretion: type I, II, III, and V secretion systems, including three type III secretion systems (including bsa, bip, and bop)
Drug resistance: Ambler class A, B, and D beta-lactamases (including oxa and penA); multidrug efflux pumps (including amr); aminoglycoside acetyltransferaseSurface components: lipopolysaccharide, capsular polysaccharide, and potential surface polysaccharide biosynthesis (including waa, rfb, and wcb)
Intracellular stress: superoxide and nitric oxide detoxification enzymes (including sod)Exoproteins: phospholipase C (including plc), metalloprotease A and other proteases (including mpr), collegenase
Motility and chemotaxis: flagellum system (including fli and flg), chemotaxis-associated proteins (including che)Adhesins: surface proteins that may modulate host-cell interaction
Fimbriae and pili: type I and IV pili and tad-type pili (including pil)
  • a For details, see National Center for Biotechnology Information Genome Project, accession numbers 006350 and 006351. Adapted from reference 197 with permission of the publisher.