TABLE 10.

Eradication-phase antibiotic regimens used for patients with normal renal function

Regimen
Royal Darwin Hospital (111)Other recommended (472)
TMP-SMX at 8/40 mg/kg (up to 320/1,600 mg) every 12 h (duration of therapy at least 3-6 months; close follow-up and monitoring of adherence are important)(i) Chloramphenicol at 10 mg/kg orally four times a day for 8 weeks, doxycycline at 2 mg/kg orally twice a day for at least 20 weeks, and TMP-SMX at 5/25 mg/kg orally twice a day for at least 20 weeksa or (ii) amoxicillin-clavulanate at 30/15 mg/kg orally tds for 20 weeks and amoxicillin at 30 mg/kg orally tds for 20 weeksb
  • a First-line regimen at Sapprasithiprasong Hospital.

  • b Second-line regimen for adults and first-line regimen for children (<14 years) and pregnant women at Sapprasithiprasong Hospital. tds, three times a day.