TABLE 8.

Clinical trials of eradication-phase oral antibiotics in treatment of melioidosis

ReferenceRegimen (dose, mg/kg/day)Duration (wk)No. of patientsRelapse rate (%)
350 Amoxicillin-clavulanate (60/15) vs chloramphenicol (40), doxycycline (4), and TMP-SMX (10/50)20 vs 2049 vs 5216 vs 4
70 Doxycycline (4) vs chloramphenicol (40), doxycycline (4), and TMP-SMX (10/50)20 vs 2058 vs 5826 vs 1
88 Azithromycin (8) and ciprofloxacin (8) vs doxycycline (4) and TMP-SMX (10/50)12 vs 2036 vs 2922 vs 3
W. Chaowagul, unpublished dataDoxycycline (4) and TMP-SMX (10/50) vs chloramphenicol (40), doxycycline (4), and TMP-SMX (10/50)12-20 vs 12-2089 vs 91No significant differences