Key differences between macular lesions and all other forms of secondary lesions

Macular lesions never appear on the face but predominate on the body and limbs
Macular lesions are transitory, generally lasting for only 2 or 3 days, as opposed to all other secondary lesions, which may last for several weeks
Treponemes are not present in macular lesions by dark-field examination
In the preantibiotic era, cutaneous Jarisch-Herxheimer reactions never occurred following arsenical injections