TABLE 4.

Reactivities obtained using different methods to detect antibodies to B. burgdorferi in Lyme borreliosis in patients from the United States

Test% Reactivity (reference[s]) in patients with:
EM, acute phaseEM, convalescent phaseaNeurological involvementArthritis
Whole-cell ELISA33-49 (7, 8, 89, 337)76-86 (7, 8, 89, 337)79 (IgG ELISA) (84)100 (IgG ELISA) (84)
IgM IBb43-44 (7, 89)75-84 (7, 89)80c (84)16c (84)
IgG IBb0-13 (7), 43.6d15-21 (7), 80d64-72 (84)96-100 (84)
Two-tier testing29-40 (7, 15, 89, 227, 337)29-78 (7, 15, 89, 227, 337)87 (15)97 (15)
  • a Sera obtained after antimicrobial treatment.

  • b IgM and IgG IB criteria are those of Engstrom et al. (89) and Dressler et al. (84), respectively, except as indicated.

  • c IgM IB criteria of Dressler et al. (84).

  • d IgG IB criteria of Engstrom et al. (89).