TABLE 6.

Selected recombinant and peptide antigens used for detection of IgM, IgG, or polyvalent antibodies to B. burgdorferi

Recombinant antigen or peptideLocationRange % positive in the indicated LB disease stageReferences
EMNeurologicalLate
IgMIgGPolyvaIgMIgGPolyvIgMIgGPolyv
OspCUnited States41-7335-43 100, 102, 183, 184, 241
Europe35-445-3547-536-337-533-60 144, 196, 244, 275
pepC10United States40-5353915
Europe36545800196
P41 internal fragmentUnited States43-5335-52 183, 184
Europe4934-60 119, 144, 273
VlsEUnited States19-4044-636373100100399787 15, 161, 185
Invariable region 6 (IR-6, C6 peptide)United States
Acute45-7460-9594-100 15, 171, 255
Convalescent70-906483-98 122, 169
Europe87
FlaA (37 kDa)United States45-6815 104
Europe2758743779 246
DbpAEurope91710093-98 122, 123
BBK32Europe1374-10010096-100 122, 123, 160
P66United States8024505735-6375-100 228
  • a Polyv, polyvalent enzyme immunoassay.