TABLE 4.

Fungal colonization in VLBW and ELBW infantsa

CharacteristicResults for study (study period)
Baley et al. (30) (1983)Hageman et al. (183) (1985)Pappu-Katikaneni et al. (362) (1991)Rowen et al. (395) (1992)Saiman et al. (402) (1993-1995)Huang et al. (215) (1996)Kicklighter et al. (255) (1998-1999)bKaufman et al. (246) (1998-2000)b
Birth wt (gr)<1,500<1,500<1,500<1,500<1,500<1,500<1,500<1,000
No. of patients146384011678011652b50b
% of patients with colonization2747633431224660
% of patients colonized with:
    C. albicans1624402618134444
    C. papapsilosis5241041363745
    C. glabrata0003<143
    C. guilliermondii0000<103
    C. lusitaniae0000011.15.1
    C. tropicalis2.102.51.703.70
Other3.40002.7c0.801.1
% of total no. of patients colonized by site:
    Skin
        Groin or axilla13.712.9048
        Umbilicus8
    Gastrointestinal tract
        Rectal19.233.63112.94554
        Stool62.5
    Respiratory tract
        Oropharyngeal1111.2d6
        Endotracheal4.811.2d2.642
    Urine8.37.7
% of total no. of patients with fungal sepsis2.17.912.56.03.12.63.916
  • a Summary of eight studies (30, 183, 215, 246, 255, 362, 395, 402).

  • b Analysis of the control patients in these randomized trials.

  • c Includes non-albicans and non-parapsilosis species.

  • d Nasopharyngeal and endotracheal cultures did not correlate with one another.