TABLE 1.

Viral and host factors that may determine virulence

FunctionViral factorsHost factors
Adsorption and penetrationCapsid proteins (VP1 to 3)Integrins, other receptors (?), entry factors (?)
TranslationLpro, IRES elementseIFs, PTBP, ITAF45
RNA replicationS region, poly(C), cre, 2B, 2C, 3A, 3B, 3Cpro, 3DpolCellular membranes, PCBP, PABP
Assembly and maturationCapsid proteins (VP0, VP1, and VP3), 3Cpro, 2A, viral RNACellular membranes (?)