TABLE 3.

IFN-α/β can rapidly protect swine from FMDV

GroupaVirus dose (PFU)bAntiviral activity at the following day postinoculationc:pIFN-α (pg/ml) at the following day postinoculationd:
012345012345
Ad5-Blue109<25<25<25<25<25<250000930
Ad5-pIFN-α108<251335825<25<2505,4881,0806500
109<258004002672525031,37213,9403,9306800
  • a Each group contained three animals.

  • b The animals were inoculated i.m. with the indicated dose of the Ad5 vector.

  • c Results are shown as the highest dilution that reduced the FMDV A12 plaque number by 50% and are averages for the three animals in each group.

  • d Results (as determined by ELISA) are averages for the three animals in each group.