TABLE 11.

Evidence of the role of short-term antibacterial treatment in ReA

ReferenceStudy designNo. of patients and diagnosisInterventionResults
55 Open, randomized, prospective40 entero-ReA (Yersinia, Salmonella, Campylobacter)No treatment versus antibacterial agents (pivampicilin, pivmecillinam, doxycycline, erythromycin, co-trimoxazole, cinxacin)No difference in duration of arthritis, grade of inflammation, number of joints involved, laboratory tests
123 Open108 enterocolitis65 treated with antibacterials (9 days) (ciprofloxacin, norfloxacin, doxycycline, co-trimoxazole, pivmecillinam- pivampicillin)No effects of antibiotics on prevention of development of arthritis
11 Retrospective224 episodes of genitourinary tract infections (60 ReA patients with urogenital infections)59 episodes, no treatment; 97 episodes, penicillin treatment; 68 episodes, erythromycin or tetracyclin therapy for at least 1 day37% of those not treated or treated with penicillin developed ReA, compared with 10% of those treated with erythromycin or tetracycline