TABLE 4.

Similarity of the mechanisms involved in the entry, traffic, replication, and exit of L. pneumophila with respect to both amoebae and macrophagesa

Life cycle stageFree-living amoebaeMacrophages
MechanismReferenceMechanismReference
EntryCoiling phagocytosis35Coiling phagocytosis120
TrafficNo phagosome-lysosome fusion35No phagosome-lysosome fusion120
PhagosomeAssociation with rough endoplasmic reticulum3Association with rough endoplasmic reticulum231
ReplicationIntraphagosomal209Intraphagosomal121
ExitHost cell lysis209Host cell lysis121
  • a The similarity suggests that the amoebae might have been the “evolutionary crib” that led to the adaptation of L. pneumophila to life within human macrophages.