TABLE 1.

Clinical and parasitologial classifications according to the WHO test protocol

Parasitological classificationsTreatment failure classifications
SensitiveAdequate clinical response (ACR)
    Clearance of parasites after treatment without subsequent recrudescence within a defined period    (i) Absence of parasitemia on day 14, irrespective of fever status, without previously meeting any of the criteria for ETF or LTF
    (ii) Absence of fever irrespective of the parasitemia status without previously meeting any of the criteria for ETF or LTF
RI parasitologic failureEarly treatment failure (ETF)
    Initial clearance followed by recrudescence after day 7    (i) Danger signs or severe malaria on day 1, 2, or 3 in the presence of parasitemia
    (ii) Fever (axillary temperature, ≥37.5°C) persists on day 2 and the parasite density is greater than that at enrollment (D0 parasite density)
    (iii) fever and parasitaemia on day 3
    (iv) parasite density on day 3 is ≥25% of the day 0 parasite density
RII parasitologic failureLate treatment failure (LTF)
    Reduction of parasitemia on day 2 to less than 25% of day 0 parasitemia, but no complete clearance    (i) Danger signs or severe malaria develop in the presence of parasitemia on any day from day 4 to day 14
    (ii) Fever and parasitemia on any day from day 4 to day 14, and yet the patient could not be classified as ETF
RIII parasitologic failures
    On day 2, either no reduction of parasitemia or reduction to a level equal to or greater than 25% of the day 0 parasitemia