TABLE 6.

P. falciparum SP treatment failure in vivo for selected countries in Africa, 1996 to 2002

RegionCountryNo. of data points identifiedPeriodAge range (yr)Outcome classificationPeriod of follow-up (days)Median % SP-PF (range)aMedian % SP-TTF (range)aSource or reference
CentralGabon11999<10WHO 19732830249
Malawi51994-19980.5-5WHO 19732810 (0-35)120, 148, 198, 213
Malawi21994-19980.5-5WHO 1996149 (0-19)119, 213
Zambia31995-20000.5-5WHO 1973, 19967, 1455 (30-70)318, 23
Eastern and great lakesKenya221998-20020.5-5WHO 1996148 (0-52) www.eanmat.org
Kenya61998-2002<12WHO 1973723 (13-38)56, 82, 150, 153
Rwanda31999-20000.5-5WHO 19961435 (12-36) www.eanmat.org
Tanzania111999-20000.5-5WHO 19961410 (1-34) www.eanmat.org
Tanzania11994-19941-10WHO 1973774178
Tanzania11997-19971-10WHO 1973142682
Tanzania31996-19991-10WHO 19732845 (31-92)122, 139, 218
Uganda161996-20020.5-5WHO 1973, 19961417 (0-73)10 (0-25)(57, 104, 111, 188, 194), Mpeka and Ndezil, (1996), personal communication; Kilian 1998, (Uganda MoH report); Priotto, personal communication, www.eanmat.org .
Zanzibar220010.5-5WHO 1996149 (5-13) www.eanmat.org
SouthSouth Africa31999-2001AllWHO 19734237 (6-92)30, 83, 119
WestBurkina Faso11998-20000.5-5WHO 1973, 1996140.60.3204
Cameroon12002<10WHO 1996140022
Cameroon12002<10WHO 19962810.315.322
The Gambia21994-19960.5-10Parasite failure at day 775 (3-6)28, 138
The Gambia21998-20010.4-18WHO 1973, 1996283355, 215
Ghana11999-20000.5-5WHO 1973, 199628291959
Nigeria21997-20011-10WHO 19731432 (24-40)3069, 192
Nigeria11997-2001AllWHO 1973142968
Senegal11996-199714-45WHO 1973280176
NorthernSomalia11997AllWHO 199614762217
  • a SP-PF, SP parasitologic failure (either R1-R3 or cumulative parasite failure); SP-TTF, SP clinical failure (either ETF + LTF or cumulative clinical failure).