TABLE 3.

CP5-specific antibodies given intraperitoneally protect against endocarditis in rats challenged with serotype 5 S. aureusa

Challenge strain and dose of S. aureus and IgG typeLog CFU/ml of blood at 24 hNo. of rats infected/totalVegetation wt (g)Log CFU/g of vegetationLog CFU/g of kidney
Reynolds (4 × 107 CFU)
    Normal4.314/40.01211.07.33
    CP-specific0.700/503.41.05
Lowenstein (6 × 107 CFU)
    Normal1.308/110.01111.07.84
    CP-specific0.704/130.0033.44.85
VP (7 × 107 CFU)
    Normal3.937/90.00910.27.20
    CP-specific0.701/903.42.06
  • a Data are adapted from Lee et al. (66) with permission.