TABLE 2.

Revised WHO guidelines for assessing the response to treatment (2002)

Early treatment failure (ETF): days 0, 1, 2, and 3
    Development of danger signs or severe malaria on days 0-3 in the presence of parasitemia
    Parasitemia on day 2 higher than on day 0, irrespective of temperature
    Parasitemia on day 3 with temperature of ≥37.5°C (axillary)
    Parasitemia on day 3 is >25% of count on day 0
Late clinical failure, (LCF): days 4 to 14 or 28
    Development of danger signs or severe malaria after day 3 in the presence of parasitaemia, without previously meeting any of the criteria of early treatment failure
    Temperature of ≥37.5°C (axillary), or history of fever in past 24 h, on days 4 to 14 or 28 in the presence of parasitemia, without previously meeting any of the criteria of early treatment failure
Late parasitological failure (LPF): days 7 to 14 or 28
    Presence of parasitemia on any day from day 7 to day 14 or 28, and temperature of < 37.5°C (axillary), without previously meeting any of the criteria of early or late treatment failure
Adequate clinical and parasitological response (ACPR)
    Absence of parasitemia on day 14 or 28, irrespective of temperature, without previously meeting any of the criteria of early or late treatment failure