TABLE 1.

Protection against abscess formation by S. aureus CP8a

ChallengeTreatment (20 μg)ChallengebNo. of rats with abscesses/total (%)P vs. saline control
HeterologousSalineCP824/27 (89)
    polysaccharideCP8CP87/19 (37)0.0003
    (20 μg)SalinePSA17/20 (85)
CP8PSA3/20 (15)<0.0001
HeterologousSalinePS8017/20 (85)
    S. aureusCP8PS806/18 (33)0.002
    (107 CFU)SalineCOL12/14 (86)
CP8COL4/15 (27)0.003
  • a Data are adapted from Tzianabos et al. (112).

  • b PSA, capsular polysaccharide A, a zwitterionic polysaccharide isolated from Bacteroides fragilis. PS80 and COL are serotype 8 and 5 S. aureus strains, respectively.