TABLE 2.

Brucella infection in gene KO or immunocompromised mice

Mouse strainFunctionDeficient phenotypesSpeciesResult of infectionReference(s)
IRF-1−/−IRF-1IL-12, IL-15, IL-18, iNOS, CD8+ T cells, NK cells B. abortus Acute death 89
IRF-2−/−IRF-2IL-12, NK cells B. abortus Resistant 89
ICSBP−/−ICSBPIL-12, ROIs B. abortus Susceptible 89
NOS2−/−iNOSNitric oxide in macrophages B. abortus Delayed control 89
gp91phox−/−NADPH oxidase componentNADPH oxidase-dependent ROIs B. abortus Delayed control 89
IL-12p40−/−IL-12 componentIL-12 B. abortus Susceptible 89
IFN-γ−/−IFN-γIFN-γ B. abortus Death (C57BL/6 and BALB/c) 113
TNFR−/−TNF receptors 1 (p55) and 2 (p75)TNF-α signaling B. abortus Susceptible 168
NF-IL-6−/−Nuclear factor IL-6G-CSF B. abortus Susceptible in vitro 127
β2-m−/−MHC class I β2-microglobulinCD8+ T cells B. abortus Susceptible to S19, resistant to S2308 113, 119
−/−MHC class II Aβ chainCD4+ T cells B. abortus Resistant 119
Rag-1−/−Recombination activation gene 1Matured B and T cells B. melitensis Susceptible 79
SCIDLacks mature B and T cellsMatured B and T cells B. abortus ResistantMorfitt et al.a
NudeThymic stroma, matured T cellsLacks matured T cells B. abortus Susceptible (persistence) 32
Perforin−/−CTL killingAbsence of perforin-mediated killing B. abortus Resistant 113
  • a D. C. Morfitt, N. F. Cheville, and A. E. Jensen, Proc. Conf. Res. Workers Anim. Dis. 72:2, 1991.