TABLE 5.

Brucella genes identified by STM

GeneFunctionSpeciesVirulenceReferences
In vitroIn vivo
ntrY Two-component system (nitrogen metabolism) B. suis AttenuatedNDa 59
glnD Uridylyl transferase (nitrogen metabolism) B. suis AttenuatedND 59
pgi Phosphoglucose isomerase (glucose metabolism) B. suis AttenuatedND 59
manB Phosphomannomutase (LPS synthesis) B. suis AttenuatedND 59
gpt Guanine phosphoribosyltransferase (nucleotide synthesis) B. suis AttenuatedND 59
LTTR-likeLysR family transcriptional regulator B. suis AttenuatedND 59
carAB Carbamoyl phosphate synthase (arginine and pyrimidine metabolism) B. suis AttenuatedND 59
rpsA Ribosomal protein S1 B. suis AttenuatedND 59
pyc Pyruvate carboxylase (glucose metabolism) B. suis AttenuatedND 59
leuA Isopropylmalate synthase (leucine synthesis) B. suis AttenuatedND 59
cysK O-Acetylserine (thiol)-lyase (amino acid metabolism) B. melitensis AttenuatedAttenuated 97
cysI Sulfite reductase (amino acid metabolism) B. melitensis AttenuatedAttenuated 97
metH Homocysteine-N5-methyltetrahydrofolate transmethylase (amino acid metabolism) B. melitensis AttenuatedAttenuated 97
mgtB Mg2+ pump (transporter) B. melitensis AttenuatedAttenuated 97
rbsC Ribose permease (transporter) B. melitensis AttenuatedAttenuated 97
ugpA Glycerol-3-phosphate permease (transporter) B. melitensis AttenuatedAttenuated 97
ccrM Adenine DNA methyltransferase (DNA metabolism) B. melitensis AttenuatedAttenuated 97
dnaJ Heat shock protein B. melitensis AttenuatedAttenuated 97
mtgA Peptidoglycan transglycosylase (membrane metabolism) B. melitensis AttenuatedAttenuated 97
vsrB Two-component system B. melitensis AttenuatedAttenuated 97
fliF Flagellar MS ring B. melitensis AttenuatedAttenuated 97
gcvB Glycine dehydrogenase B. abortus NDAttenuated 75
gluP Glucose/galactose permease B. abortus NDAttenuated 75
wbkA LPS synthesis B. abrotus NDAttenuated 75
gltD Glutamate synthase B. abortus NDAttenuated 75
  • a ND, not determined.