TABLE 3.

Brucella antigens that induce a B-cell response

AntigenFunctionSpeciesSerum hostProtectionReference(s)
Omp19Outer membrane protein B. abortus Mouse, goat, dog, humanNDa 94
Omp25Outer membrane protein B. ovis MouseYes 18
Omp28Outer membrane protein B. melitensis HumanND 102
Omp31Outer membrane protein B. ovis RamYes 88
Omp89Outer membrane protein B. abortus CattleND 100
CP24Ribosome-releasing factor B. melitensis SheepND 159
HtrAHeat shock protein B. abortus, B. melitensis, B. canisMouse, cattle, goat, dogND 138
18-kDa proteinLumazine synthase B. ovis, B. canis Human, cattleND 8, 66, 67
BCSP31Unknown Brucella spp. except B. ovisRabbitND 20
DnaKHeat shock protein B. melitensis, B. ovisMouse, sheepND 155, 160
BP26 (CP28)Periplasmic or cytoplasmic protein B. abortus, B. melitensis Cattle, human, ramND 42, 140
17-kDa proteinUnknown B. abortus, B. melitensisSheep, cattleND 70
22.9-kDa proteinUnknown B. abortus UnknownYesb 30
32.2-kDa proteinUnknown B. abortus UnknownNo 30
20-kDa protein (antigen A-2)Unknown B. melitensis UnknownND 148, 173
Dihydrolipoamide succinyltransferaseDihydrolipoamide succinyltransferase B. ovis MouseND 155
31-kDa proteinUnknown B. ovis UnknownND 155
Malate dehydrogenaseMalate dehydrogenase B. ovis UnknownND 155
Succinyl coenzyme A synthetase alpha subunitSuccinyl coenzyme A synthetase alpha subunit B. ovis UnknownND 155
ABCa-type transporterABC-type transporter B. ovis UnknownND 155
Leu/Ile/Val-binding-protein precursorLeu/Ile/Val-binding-protein precursor B. ovis UnknownND 155
ClpPStress protein B. ovis UnknownND 155
NikANickel transport B. ovis UnknownND 155
  • a ND, not determined; ABC, ATP-binding cassette.

  • b With Freund’s adjuvant.