TABLE 2.

Substrate profiles of aminoglycoside acetyltransferases

AcetyltransferaseSubstrate(s)
AAC(6′)
    I (at least 24 different enzymes)Tobramycin, amikacin, netilmicin, dibekacin, sisomicin, kanamycin, isepamicin
    IITobramycin, gentamicin, netilmicin, dibekacin, sisomicin, kanamycin
AAC(3)
    Ia, IbGentamicin, sisomicin, fortimicin
    IIa, IIb, IIcTobramycin, gentamicin, netilmicin, dibekacin, sisomicin
    IIIa, IIIb, IIIcTobramycin, gentamicin, dibekacin, sisomicin, kanamycin, neomycin, paromomycin, lividomycin
    IVTobramycin, gentamicin, netilmicin, dibekacin, sisomicin, apramycin
    VIIGentamicin
AAC(1)Paromomycin, lividomycin, ribostamycin, apramycin
AAC(2′)-IaTobramycin, gentamicin, netilmicin, dibekacin, neomycin