TABLE 3.

Substrate profiles of aminoglycoside nucleotidyltransferases

NucleotidyltransferaseSubstrate(s)
ANT(2′′)-ITobramycin, gentamicin, dibekacin, sisomicin, kanamycin
ANT(3′)-IStreptomycin, spectinomycin
ANT(4′)-IaTobramycin, amikacin, dibekacin, kanamycin, isepamicin
ANT(4′)-IIaTobramycin, amikacin, kanamycin, isepamicin
ANT(6′)-IStreptomycin
ANT(9)-ISpectinomycin