TABLE 2.

Common mammalian lipoxygenase products and their functionslegend

NameReceptorCellular targetFunction
LTB4B-LT1NeutrophilsLysosomal enzyme release, superoxide production, chemotaxis, chemokine production
B-LT2LeukocytesAggregation and chemotaxis
Many cell types?
LTC4?Lung cellsMediator of asthma and allergic responses; promotes anaphylaxis, smooth muscle contraction, bronchoconstriction, vascular permeability, hypersensitivity.
LTD4Cys-LT1Lung smooth muscle, endothelial cellsMediator of asthma and allergic responses; promotes anaphylaxis, smooth muscle contraction, bronchoconstriction, vascular permeability, hypersensitivity
Cys-LT2Heart, adrenal, brain, spleen cells?
LTE4?Lung cellsMediator of asthma and allergic responses; promotes anaphylaxis, smooth muscle contraction,
bronchoconstriction, vascular permeability, hypersensitivity, chemoattractant for eosinophils
5-HETE?GranulocytesProliferative and chemotactic effects
12-HETE?Tumor cellsEnhances tumor cell adhesion
15-HETE??Produced during allergic rhinitis
  • legend aAdapted from Funk et al. (40, 87).