TABLE 1.

EPEC virulence genes

GeneAlternative or previous nameFunctionReference(s)
bfpABFP biogenesis, major pilus subunit—bundlin40
bfpBBFP biogenesis, outer membrane140, 155
bfpCBFP biogenesis, inner membrane140
bfpDBFP biogenesis162, 168
bfpEBFP biogenesis, inner membrane scaffold and transporter15, 140
bfpFRequired for dissociation of BFP bundles7, 14
bfpGBFP biogenesis, outer membrane140
bfpHFunction unknown162, 168
bfpIBFP biogenesis, inner membrane140
bfpJBFP biogenesis, inner membrane140
bfpKBFP biogenesis, inner membrane140
bfpLBFP biogenesis, inner membrane140
bfpUBFP biogenesis, periplasmic140, 156
bfpPBFP biogenesis, prepilin peptidase193
bfpTperARegulator of bfp and ler72, 162, 177
bftVperBAccessory factor for PerA72, 177
bfpWperCAccessory factor for PerA72, 177
escCsepCTTSS biogenesis49
escDsepETTSS biogenesis49
escForf28TTSS biogenesis, needle component158, 188
escJsepDTTSS biogenesis49
escNsepBTTSS biogenesis49
escRsepITTSS biogenesis49
escSsepHTTSS biogenesis49
escTsepGTTSS biogenesis49
escUsepFTTSS biogenesis49
escVsepATTSS biogenesis49
sepQTTSS biogenesis49
sepZTTSS biogenesis49
eaeeaeAAdhesin binds Tir—intimin90
tirTranslocated intimin receptor; initiates actin pedestal formation103
espAForms filaments between bacteria and host; delivery of effector molecules57, 107
espBeaeBTranslocation pore; host cytosolic effector(?)57, 88, 174
espDTranslocation pore57, 88
espForf30Disrupts tight-junction integrity; induces cell death31, 121
espGrorf2Effector molecule (function unknown)46
maporf19Damages mitochondria membrane integrity; induces filopodia formation94, 99, 102
lerorf1Regulator for LEE genes and espC48
cesDsepEChaperone for EspB and EspD184
cesTorf21Chaperone for Tir36
cesFrorf10Chaperone for EspF47