TABLE 4.

Susceptibility of planktonic and biofilm bacteria to selected antibiotics

ReferenceOrganismAntibioticMIC or MBC of planktonic phenotype (μg/ml)Concn effective against biofilm phenotype (μg/ml)
215 S. aureus NCTC 8325-4Vancomycin2 (MBC)20a
26 Pseudomonas aeruginosa ATCC 27853Imipenem1 (MIC)>1,024b
26 E. coli ATCC 25922Ampicillin2 (MIC)512b
208 P. pseudomallei Ceftazidime8 (MBC)800c
114 Streptococcus sanguis 804Doxycycline0.063 (MIC)3.15d
  • a Concentration required for 99% reduction.

  • b Minimal biofilm eradication concentration.

  • c Concentration required for ∼99% reduction.

  • d Concentration required for >99.9% reduction.