TABLE 9.

Studies examining the cellular immune response to Malassezia in patients with PV and controls

ReferenceSubjectsMethodAntigenic preparation and strain usedResults
40912 PV, 15 controlsLTEther extraction, physical disruption, dialysis and lyophilization of P. ovale and P. orbiculare (clinical isolates)No differences in responses between patients and controls
LMIResponses to P. orbiculare significantly lower in patients than controls (P < 0.001)
41118 PV, 42 controlsLTEther extraction, physical disruption, dialysis, and lyophilization of P. ovale and P. orbiculare (clinical isolates)Lower responses to P. orbiculare in patients than controls on day 6 but not day 9 (peak response)
47731 PV, 30 controlsLT“Crude extract” of P. orbiculareHigher “lymphocyte responsiveness” in patients than controls
2810 PV, 10 controlsLMIWhole cells of M. furfur serovars A, B, and CNo differences between patients and controls
LTMore patients than controls responded to serovar B (P < 0.05)
4612 PV, 12 controlsLTFreeze-pressed cells of M. furfur (ATCC 42132)Stimulation significantly lower in patients than controls (P < 0.001)
37812 PV, 12 controlsLMIMycelia from strains Hook (M. furfur)No difference in responses between patients and controls
LTGM 216 (M. obtusa), and 2.PV.WY (M. sympodialis), all serovar APatients had higher response to all three antigens than did controls (P < 0.05)