TABLE 4.

HLA class II associations with IBD

HLA definitionAssociation with disease
Serologic specificityDNA genotypesUCCP
DR103DRB1*0103Positive
DR2aDRB1*1501–DRB1*1504Positive to DR2 overallNegative association with DR2
DRB1*1601–DRB1*1606Positive to DR15, negative to DR16; positive to DRB1*1501, DRB1*1502
DR7DRB1*0701Positive
DR9DRB1*0901Positive
DR52cDRB3*0301Positive
  • a Serologic subtype DR2 can be subtyped as DR15 or DR16.