TABLE 1.

Diagnostic criteria for C. pneumoniae infection used in prospective seroepidemiologic studies

StudyYrNo. of patientsSerologic test (isolate)Cutoff titerComments
Saikku et al. (125)1992102MIF (TW 183)IgG ≥ 16IgA > 64 considered chronic infection
LPS ICaIgA ≥ 8
Meittinen et al (93)1996202MIF (Kajaani 6)IgG ≥ 32IgG ≥ 128 and IgA ≥ 40 considered elevated
IgA ≥ 10
Gupta et al. (44)199720MIF (IOL-207)IgG ≥ 8
IgG > 64
Ossewaarde et al. (103)199854EIA (TW 183)NSb
Strachan, et al. (132)1999278MIF (NS)IgG ≥ 16
IgA ≥ 16
Ridker et al. (117)1999343MIF (NS)IgG ≥ 16
Ridker et al. (118)1999122MIF (NS)IgG > 16 to IgG 128
Altman et al. (1)1999227Whole-cell IF (CWL-029)IgG ≥ 32
Nieto et al. (99)1999246MIF (TW 183)IgG ≥ 8IgG ≥ 8–32 considered low positive
IgG ≥ 64 considered high positive
Glader et al. (41)200078ICIgG ≥ 32IgG antibodies were detected in IC by MIF (Kajaani 6)
EIA (Medac rELISA)IgA (0.7 ODc)
Danesh et al. (23)2000496TRFIgG—NS
Wald et al. (141)2000647TRFIgG—NS
IgA—NS
Choussat et al. (20)200071MIF (NS)IgG—NS
IgA—NS
IgM—NS
Siscovick et al. (131)2000213MIF (TW183)IgG ≥ 8IgG ≥ 8 considered past infection
  • a IC, immune complex.

  • b NS, not specified.

  • c OD, optical density.