TABLE 2.

Examples of animal IBD models

Spontaneously occurring
    C3H/HeJBir mouse strain
    SAMP1/Yit strain mice
Treatment with mucosal-injuring agents
    Trinitrobenzene sulfonic acid (TNBS) enemas
    Dextran sulfate sodium (DSS) administration
Alteration of cytokine function
    IL-10 knockout mouse
    IL-2 knockout mouse
    TNF ΔARE mice
    STAT-4 transgenic mice
Alteration of T-cell function
    T-cell receptor α knockout mouse
    T-cell receptor β knockout mouse
    HLA-B27 transgenic rat
    Transfer of CD4+ CD45RBhi cells into SCID or Rag−/− mice
Impairment of epithelial barrier function
    Mutated multidrug-resistant gene mice
    Intestinal trefoil factor knockout mice