TABLE 2.

Virulence of F. tularensis biotypesa

Biotype50% lethal dose, CFU (reference[s])
HumansMiceGuinea pigsRabbits
Francisella tularensis subsp. tularensis<10 (74)<10 (100)<10 (100)1-10 (100, 130, 151)
Francisella tularensis subsp. holarctica<103 (40)<1 (100)<10 (100)>106 (100, 130)
Francisella tularensis subsp. mediaasiaticaNRNRNR>106 (151)
Francisella tularensis subsp. novicida>103 (40)<103 (40)<103 (40)>103 (40)
  • a All doses were given subcutaneously. NR, not reported.