Table 10.

Suppression of systemic immunologic reactivity: induction of mucosal tolerance with oral antigen feedinga

SpeciesDiseaseAntigen fed orallyBeneficial effectb
HumanMultiple sclerosisBovine myelin±
Mouse or ratEAEMBP+++
HumanType I diabetesInsulin
MouseDiabetesInsulin++
HumanUveitisBovine S-antigen+
MouseEAUIRBP++
HumanRheumatoid arthritisChicken type III cartilage+
MouseCollagen-induced arthritisType II collagen peptides+++
MouseColitisHaptenized colonic protein++
MouseThyroiditisThyroglobulin++
RatTransplantationAlloantigens-MHC peptides++
  • a Data taken from reference90.

  • b −, not known; ±, some; +++, highly significant.