Table 1.

Efficacy of anti-Giardia drugs in adult and pediatric infectiona

DrugDosebMedian efficacy (%)cEfficacy range (%)
Metronidazole500–750 mg/day × 5–10 days8860–95
2.0–2.4 g, single dose4836–60
2.0–2.4 g, q.d. × 2 days7167–80
2.0–2.4 g, q.d. × 3 days93–100
15–22.5 mg/kg/day × 5–10 daysd9480–100
Tinidazole300 mg/day × 7 days8774–100
1.0–2.0 g, single dose9286–100
50 mg/kg, single dosed9180–96
Ornidazole1.0–2.0 g, single dose96–100
40–50 mg/kg, single dosed92–100
Secnidazole2.0 g, single dose86–100
30 mg/kg, 1 or 2 dosesd88–100
Quinacrine300 mg/day × 5–7 days95–100
6–8 mg/kg/day × 5–10 daysd92–95
Furazolidone400 mg/day × 7–10 days80–85
8 mg/kg/day × 7–10 daysd9281–96
Albendazole200–800 mg/day × 1–3 days24–81
200–400 mg/day × 5–7 days94–100
Paromomycin10–50 mg/kg/day or 1,500 mg/day × 5–10 days55–88
Bacitracin zinc240,000 U/day × 10 days95
  • a Efficacy is based on studies that may vary in design, entry methodology, or outcome measure. When separate pediatric populations were studied, they are designated. See the text for references.

  • b Doses are total daily amounts, which may or may not have been given in divided doses. Actual treatment recommendations are presented in Table 2. q.d., once a day.

  • c Median efficacy is given when the results of four or more studies are included.

  • d Pediatric population only.