Table 1.

Group A streptococcal adhesins and their host cell receptors

AdhesinHost cell receptorCommentReference(s)
LTAEpithelial cell/fibronectin receptor27, 488
M proteinHEp-2 cellsIL-6 production110, 418, 540
Keratinocytes/CD46 receptor/factor HIL-1 and prostaglandin E2 production168, 400, 401
Protein F/SfbIEpithelial cell/fibronectin/CD46 receptor on keratinocytes223, 224, 400
Fibronectin-binding protein (FBP54)Fibronectin/fibrinogen109
Serum opacity factorFibronectin311, 446
Hyaluronic acid capsuleKeratinocyte/CD44 (hyaluronate receptor)471, 549
Glyceraldehyde-3-phosphate dehydrogenasePharyngeal epithelium/fibronectin/cytoskeletal proteins/plasminogen-plasmin412, 563
Fibronectin-binding protein (29 kDa)Fibronectin105
Vitronectin-binding proteinVitronectin526
70-kDa galactose-binding proteinGalactose201, 535
Collagen-binding proteinCollagen533