Table 3.

Estimated worldwide yearly toll of invasive Hib infections before the conjugate vaccine era

DiseaseDeveloped regionsaDeveloping regionsaWhole world
0–4-yr-old children (83 × 106)bAll age groups (1,250 × 106)0–4-yr-old children (550 × 106)All age groups (4,500 × 106)0–4-yr-old children (630 × 106)All age groups (5,700 × 106)
Meningitis
 Incidence322.5607.5570.7
 No. of cases27,00032,000330,000337,000357,000369,000
 No. of deaths1,3003,200100,000101,000101,300104,200
 Case fatality rate (%)51030302828
Epiglottitis
 Incidence131<1<120.2
 No. of cases11,00013,0001,0001,00012,00014,000
 No. of deaths200300200200400500
 Case fatality rate (%)2220202.53
Other entities excluding nonbacteremic pneumonia
 Incidence121122122
 No. of cases10,00013,00066,00090,00076,000103,000
 No. of deaths2005006,6009,0006,8009,500
 Case fatality rate (%)24101099
Pneumonia
 Incidence6c 1300d 4530035
 No. of cases5,00013,0001.7 × 106 1.7 × 106 1.7 × 106 1.7 × 106
 No. of deaths250600220,000–400,000ca. 400,000220,000–400,000ca. 400,000
 Case fatality rate (%)5513–2413–2413–2413–24
Total
 Incidence excluding pneumonia574.5729713
 No. of cases excluding pneumonia48,00058,000397,000428,000445,000486,000
 No. of deaths excluding pneumonia1,7004,000106,800110,200108,500114,200
 Case fatality rate (%)4725252423
 Incidence including pneumonia635.53705537040
 No. of cases including pneumonia53,00070,0002.1 × 106 2.1 × 106 2.2 × 106 >2.2 × 106
 No. of deaths including pneumonia2,0004,650325,000–500,000510,000340,000–515,000>520,000
 Case fatality rate (%)4715–252015–2320
  • a World Bank categorization (20).

  • b Values in parentheses give the populations for each group.

  • c Probably an underestimate.

  • d Applying the earlier conservative Gambian estimate (65), which is lower than that reported later in Gambia (115) or in Papua New Guinea (101), and closer to that among Australian Aborigines (68).