Table 4.

Annual cases prevented by conjugate vaccines in children aged 0 to 4 yearsa

Area and yr of comparisonNo. of children 0–4 yr oldIncidence before vaccinationbNo. of cases/yr before vaccinationIncidence after vaccinationb
MeningitisAll entitiesMeningitisAll entitiesMeningitisAll entities
Europe
 Scandinavia,c 1970s vs. 19951,581,0003151490810<1≈1
 Austria, Vienna, 1991 vs. 1993–1996485,0001155<1
 France
  Val-de-Marne, 1980s vs. 1992–199345,00021–2518≈4
  Whole countryd 3,777,00023>500870≈4
 Germany
  Rhein-Main area, 1989 vs. 1993–1995100,00033330.81
  Whole countryd 4,115,00023469501,9000.91.3
 Ireland, 1991–1993 vs. 1995260,00025652.6
 The Netherlands, 1970s vs. 1993–1994981,00022–40803907800.3≈1
 Spain, Basque region, 1993–1995 vs. 199780,00014211318≈02
 Switzerland, 1976–1990 vs. 1991–1993447,00026841153758≈10
 United Kingdom
  England and Wales, 1991–1992 vs. 1993–19943,434,00015315151,0600.62
  Whole countryd 3,831,00024369201,3800.6≈1
The Americas
 North
  Canada, 1985 vs. 1994d 2,026,000≈44≈85≈900≈1,750<1≈2
  United States
   20 states, 1980s vs. 19917,600,00019–241,334–1,7623.7
   Minnesota, 1983–1987 vs. 19916221011
   Dallas County, 1983–1987 vs. 1991911509
   Whole country, 1987 vs. 199520,524,000548812,00019,500<11.6
 South
  Brazil, Curitiba, 1988–1996 vs. 1997125,000222910
  Chile, 1995 vs. 19981,500,00040580<2
  Costa Rica, 1992 vs. 1994417,000≈45≈1006379
  Uruguay, 1992–1993 vs. 1995261,00017–22431
Asia
 Israel 1989–1992 vs. 1995566,000183490170<1<1
 Qatar 1991–199650,000≈2010<2
Oceania
 Australia
  Sydney region, 1991–1992 vs. 1993–1994264,000214255110616
  Whole countryd 1,360,0002559340800616
Total42,386,000≈24,000
Estimated elsewhere in Europe and in other countries with significant vaccination activity
Grand total
No. of cases prevented by vaccination/yrReference(s)
Meningitis  All entities
470770 136
50 93, 178
15 138; Boucher et al., abstract
420720
9001,800 82,176a, 189
60 53
385770 5, 74
1316Arı́stegui and Muniozguren, abstract
80330 43
500990 18, 19, 71, 167, 173
8951,340
8801,710 80; Scheifele, personal communication
≈1,200 175
175 117
130135 117
11,80019,200 14, 28, 31
19 17a
560 9a
4045 26; Odio et al., abstracte
35 126
≤90165 37, 38
8Levine, personal communication
4070Hogg et al., abstract
300580 31, 109; Hogg et al., abstract
≈16,000≈28,000
5,00010,000
≈21,000≈38,000
  • a Mostly my own estimations.

  • b Incidence per 100,000 per year.

  • c Denmark, Finland, Iceland, Norway, and Sweden; information analyzed in detail in reference136.

  • d Assuming a similar effect to that in the given areas.

  • e C. M. Odio, E. Mohs, L. Ramı́rez, M. Herrera, and I. Faingezicht, Pediatr. Res. 31:98A, 1992 (abstract).