Table 1.

Differentiating features of the zygomycetes,Aspergillus spp., and Candida spp. in tissue sections

Morphologic characteristicZygomycetesAspergillusspp.Candida spp.
Hyphal typeAseptate or nearly aseptate hyphae; may also present as gnarled or “crinkled cellophane” balls in specimensSeptate hyphaePseudohyphae
Hyphal widthVariable and wide (6–16 μm wide)Consistently thin (2–3 μm wide)Consistently thin (2–3 μm wide)
BlastoconidiaAbsentAbsentPresent
Sporulation or conidiationAbsent in tissueMay be present if infected space communicates with airNot applicable
AngioinvasionPresentPresentMay be present