Table 5.

Effects of antibacterial agents on the specific immune system and complement activation

FunctionDrugs that increase functionDrugs that decrease function
In vitro
 Complement inactivationSulfonamides, tetracycline, ampicillin, streptomycin, gentamicin
 T and B lymphocytesCefotaxime, cefodizime, erythromycin A, fosfomycin, dapsone, ciprofloxacinCefmenoxime, josamycin, fusidic acid, cyclines, chloramphenicol, rifampin, clofazimine, co-trimoxazole, ampicillin
In vivo, ex vivo
 T and B responsesCefotaxime, cefodizime, dapsone, erythromycin ACyclines, ampicillin, mezlocillin, clofaximine
 Graft survivalChloramphenicol, fusidic acid, doxycycline, rifampinTrimethoprim, rifampin
 Tumor growthMezlocillin, doxycycline, rifampinTrimethoprim, rifampin
 Antibody protectionCefotaxime, cefodizimeChloramphenicol, co-trimoxazole, rifampin, josamycin, doxycycline
 Delayed-type hypersensitivityCefodizimeMezlocillin, cyclines, metronidazole, rifampin, erythromycin A
  • a Restoration in immunocompromised animals.

  • b Depends on the administration schedule.