Table 4.

In vitro effects of antibacterial agents on phagocyte functions

FunctionDrugs that increase functionDrugs that decrease functionDrugs with no effect on function
ChemotaxisNafcillin, clindamycin, erythromycin, bacitracin, chloramphenicol, dapsone, lincomycinTetracycline, clindamycin, erythromycin, gentamicin, fusidic acid, clofazimineTetracycline, clindamycin, erythromycin, gentamicin, chloramphenicol, quinolones, rifampin, β-lactams
PhagocytosisErythromycin, chloramphenicol, nafcillinTetracycline, tobramycin, polymyxin BTetracycline, gentamicin, polymyxin B, rifampin
Oxidative burstClindamycina, cefotaxime, quinolones, cefpimizole, josamycinCyclines, cefotaximeb, trimethoprim, rifampin, fusidic acidc, sulfonamides, chloramphenicol, erythromycin A (and derivatives)Cyclines, clindamycin, quinolones, rifampin, fusidic acid, sulfonamides, chloramphenicol, spiramycin, glycopeptides, aminoglycosides
Bacterial killingdCefotaxime, cefodizime, roxithromycinSulfonamides, aminoglycosidesRifampin, polymyxin
CytokineseCefotaxime (IL-1), cefaclor (IL-1), cefodizimef (IL-1, IFN), erythromycin A derivatives (IL-10), ofloxacin (IL-2), spiramycin (IL-6)Cefoxitin, cefodizime (IL-1, -8, TNF), erythromycin A derivatives (IL-1, IL-6, IL-8, TNF), ofloxacin, ciprofloxacin (IL-1, TNF)
  • a Depends on concentrations.

  • b In monocytes.

  • c In PMN.

  • d Depends on bacterial species.

  • e Depends on cytokines.

  • f Restoration in immunocompromised animals.