Table 2.

Azole antifungal agents for systemic mycoses

Clinical useKetoconazoleItraconazoleFluconazole
Aspergillosisa
Candidiemiab,c
Cryptococcosisd
Blastomycosisa,d,e a d
Histoplasmosisa,d,e a b
Coccidioidomycosisa
Paracoccidioidomycosisd b
Sporotrichosisb
Pseudallescheriasisd
  • a Not for meningeal infection.

  • b Promising, but clinical studies needed.

  • c Lack of i.v. formulation at present limits use in seriously ill patients.

  • d Second-line azole.

  • e Nonimmunosuppressed hosts only.